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… is fully applicable to other glycoproteins, such as mAbs, ADCs, and other proteins produced by the recombinant …
Protein aggregation
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… Biologics, and in particular monoclonal antibodies (mAbs), are an important class of therapeutics, and their … validated software was used for the characterisation of mAbs in complex mixtures at the intact and subunit levels … Two approaches were developed to characterise mAbs with mass spectrometry using innovative two-dimensional …
WEBINAR: HDX-MS: a powerful tool for biopharmaceutical characterisation
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… (HDX-MS): a powerful tool for biopharmaceutical characterisation Hydrogen-Deuterium Exchange Mass … technique for the advanced structural characterisation of proteins and the study of protein-protein interactions. This technique has been used …
Mass spectrometry as a powerful tool for the characterisation of monoclonal antibodies in the context of comparability studies
Article
… glycoengineering of therapeutic antibodies and Fc-fusion proteins. Curr. Pharm. Biotechnol. 9, 482–501 (2008) … In …
Oligonucleotides: A serious analytical challenge in terms of analytical characterisation
Article
… Oligonucleotides: A serious challenge in terms of analytical … by Arnaud Delobel , R&D Director at Quality Assistance S.A. Oligonucleotides are a promising class of therapeutics that … we solely focus on the analytical characterisation of oligonucleotides and on the development and validation of …
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… Abstract Almost 60% of commercialized pharmaceutical proteins are glycosylated. Glycosylation is considered a … as it affects the stability, bioactivity and safety of proteins. Hence, the development of analytical methods to characterise the composition and structure of glycoproteins is crucial. Currently, existing methods are …
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… Host-cell proteins are a major class of process-related impurities in … be used for routine testing of residual HCPs in therapeutic proteins is appropriate. Compared to traditional Western … Blot approaches with visual comparisons of the gels (total proteins vs. proteins detected by the antibodies), the …
Advanced Analytical Technologies for Proteins 2019
Events
… Assistance attended Advanced Analytical Technologies for Proteins conference Quality Assistance is the one-stop shop … trust our excellence and know-how in analysing their proteins . From discovery to the marketplace, Quality … Arnaud Delobel, R&D Director, presented on the structural characterisation and epitope mapping by HDX-MS. Contact us …