Characterisation of proteins by MS
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… range of technologies to fully characterise therapeutic proteins. Whether you are interested in monoclonal … antibodies (mAbs), antibody-drug conjugates (ADCs), fusion proteins, small or large proteins, Quality Assistance has the tools to support you …

Mass Spectrometry protein characterisation at Quality Assistance

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… and have developed a set of analytical workflows for the characterisation of biotherapeutics , with a strong focus … on: monoclonal antibodies antibody-drug conjugates fusion proteins These workflows can serve as generic methods in … sound expertise in Mass Spectrometry. … Mass Spectrometry protein characterisation at Quality Assistance … resource …

PEGylated Proteins
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… is a great tool to improve the delivery of therapeutic proteins, but it adds a level of complexity to the product. … In addition to all the analytical tests proposed for proteins, Quality Assistance has developed specific methods for the analysis of PEGylated proteins using state-of-the-art analytical techniques, such …

Characterisation of Anti-HCP antibodies by 2D differential Gel Electrophoresis

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… Host-cell proteins are a major class of process-related impurities in … be used for routine testing of residual HCPs in therapeutic proteins is appropriate. Compared to traditional Western … Blot approaches with visual comparisons of the gels (total proteins vs. proteins detected by the antibodies), the …

Characterisation of Humira Adalimumab by high resolution mass spectrometry

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… use of mass spectrometry as a powerful tool for adalimumab characterisation is presented. Humira ® (adalimumab) is an … recombinant antibody expressed in CHO cells. As for all proteins produced via recombinant DNA technologies, the … a technique that is now widely used for biopharmaceuticals characterisation. Thanks to innovations in both hardware and …